Sepilok Orangutan Rehabilitation Centre is located about 25 kilometres west of Sandakan in the state of Sabah, Malaysia.

The centre opened in 1964 as the first official orangutan rehabilitation project for rescued orphaned baby orangutans from logging sites, plantations, illegal hunting or kept as pets.The orphaned orangutans are trained to survive again in the wild and are released as soon as they are ready. The sanctuary is located within the Kabili-Sepilok Forest Reserve which covers an area of 4,294 ha (10,610 acres), much of which is virgin rainforest. Today around 60 to 80 orangutans are living free in the reserve. It has become one of Sabah's tourist attractions.

In October 2014 the centre opened a new section where visitors can view the nursery area where the younger Orangutans first learn to be outside and play on a large climbing frame. This consists of 2 large indoor seating areas (one with air conditioning and one with fans only) with a large window that overlooks the play area. There is no additional charge to enter this part of the centre.

The Orangutan Rehabilitation Centre is neighboured to the Bornean Sun Bear Conservation Centre and shares veterinary facilities, personnel, parking, access roads and ticket gates. 

The Bornean Sun Bear Conservation Centre is a wildlife conservation and research centre for improving animal welfare and rehabilitation of the Malayan sun bear (Helarctos malayanus). It also aims to raise public awareness about the plight of the sun bears and to raise conservation awareness about this species.

The BSBCC was established as a non-profit organisation in Sabah in 2008. It is a joint project between sun bear researcher Wong Siew Te, Land Empowerment Animals People (LEAP), the Sabah Wildlife Department (SWD) and the Sabah Forestry Department (SFD).